"Once a disorder exists, and the brain has changed, the changes have to be dealt with in some way in order for a patient to recover. Drugs can induce adaptive changes in neural circuits, or put neural circuits in a state where adaptation and learning are promoted. But there's no guarantee that, left to its own devices, the brain will learn the right things. Patient's in other words, are likely to benefit most from drug therapy when the drug-induced adaptivity of their brains is directed in meaningful way. This is probably best achieved by traveling down the pharmacological road to recovery with someone who understands not just the drug or the person, but the drug, the person ,and the life situation the person is experiencing."
LeDoux from Synaptic Self pp. 300-301